DNA damage in Wistar Kyoto rats exercised during pregnancy
Acta cir. bras
;
32(5): 388-395, May 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-837711
ABSTRACT
Abstract Purpose:
To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program.Methods:
Wistar Kyoto rats were allocated into two groups (n= 5 animals/group) non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage.Results:
Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p<0.05).Conclusion:
The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Dano ao DNA
/
Teste de Esforço
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual Paulista/BR
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