Lichen planopilaris-like eruption during treatment with tyrosine kinase inhibitor nilotinib
An. bras. dermatol
;
91(5,supl.1): 45-47, Sept.-Oct. 2016. graf
Artigo
em Inglês
| LILACS
| ID: biblio-837937
ABSTRACT
Abstract Tyrosine kinase inhibitors are effective as a target therapy for malignant neoplasms. Imatinib was the first tyrosine kinase inhibitor used. After its introduction, several other drugs have appeared with a similar mechanism of action, but less prone to causing resistance. Even though these drugs are selective, their toxicity does not exclusively target cancer cells, and skin toxicity is the most common non-hematologic adverse effect. We report an eruption similar to lichen planopilaris that developed during therapy with nilotinib, a second generation tyrosine kinase inhibitor, in a patient with chronic myeloid leukemia resistant to imatinib. In a literature review, we found only one report of non-scarring alopecia due to the use of nilotinib.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pirimidinas
/
Toxidermias
/
Inibidores de Proteínas Quinases
/
Líquen Plano
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Private clinic/BR
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