Fluconazole prophylaxis in preterm infants: a systematic review
Braz. j. infect. dis
;
21(3): 333-338, May-June 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-839209
ABSTRACT
ABSTRACT Objective:
This article aims to review the use of antifungal prophylaxis with intravenous fluconazole in premature newborns and the occurrence of Invasive Candidiasis.Methods:
This is a systematic review with search at databases PubMed, Capes Portal, Virtual Health Library (BVS - Biblioteca Virtual em Saúde)/Lilacs, Scopus and Cochrane. The keywords used were "Antifungal", "Candida" "Fluconazole prophylaxis" and "Preterm infants".Results:
Invasive Candidiasis was evaluated in all the twelve items. In eleven of them, there was a statistically significant difference between the groups receiving prophylactic fluconazole, with lower frequency of Invasive Candidiasis, compared to placebo or no prophylaxis group. Colonization by Candida species was also evaluated in five studies; four of them presented statistically lower proportion of colonization in patients with Fluconazole prophylaxis, compared to placebo or no drugs. In one study, there was a significant difference, favoring the use of fluconazole, and reduction of death.Conclusion:
Studies indicate the effectiveness of prophylaxis with fluconazole, with reduction in the incidence of colonization and invasive fungal disease. The benefits of prophylaxis should be evaluated considering the incidence of candidiasis in the unit, the mortality associated with candidiasis, the safety and toxicity of short and long-term medication, and the potential for development of resistant pathogens.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Recém-Nascido Prematuro
/
Fluconazol
/
Candidíase Invasiva
/
Doenças do Prematuro
/
Antifúngicos
Tipo de estudo:
Ensaio Clínico Controlado
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
/
Recém-Nascido
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Minas Gerais/BR
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