Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise
Motriz (Online)
;
23(spe): e101609, 2017. ilus
Artigo
em Inglês
| LILACS
| ID: biblio-841856
ABSTRACT
Abstract Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other outcomes.This transporter migrates to the plasma membrane and assists in glucose internalization.However, under special conditions such as physical exercise, alterations in the levels of intracellular molecules such as ATP and calcium actto regulate GLUT4 translocation and glucose uptake in skeletal muscle, regardless of insulinlevels.Regular physical exercise, due to stimulating pathways related to glucose uptake, is an important non-pharmacological intervention for improving glycemic control in obese and diabetic patients. In this mini-review the main mechanisms involved in glucose uptake in skeletal muscle in response to muscle contraction will be investigated.(AU)
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Exercício Físico
/
Músculo Esquelético
/
Metabolismo Energético
/
Glucose
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Motriz (Online)
Assunto da revista:
EducaÆo F¡sica e Treinamento
/
Medicina Esportiva
/
Medicina F¡sica e ReabilitaÆo
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual de Campinas/BR
/
Universidade de São Paulo/BR
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