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Parental age is related to the occurrence of cleft lip and palate in Brazilian populations
Carvalho, Paulo Henrique Pimenta de; Machado, Renato Assis; Reis, Silvia Regina de Almeida; Martelli, Daniella Reis Barbosa; Dias, Verônica Oliveira; Martelli-Júnior, Hercílio.
  • Carvalho, Paulo Henrique Pimenta de; Universidade Estadual de Montes Claros. Center of Biological and Health Sciences. Montes Claros. BR
  • Machado, Renato Assis; Universidade Estadual de Campinas. Piracicaba Dental School. Department of Oral Diagnosis. Piracicaba. BR
  • Reis, Silvia Regina de Almeida; Escola Bahiana de Medicina e Saúde Pública. Department of Basic Science. Salvador. BR
  • Martelli, Daniella Reis Barbosa; Universidade Estadual de Montes Claros. Center of Biological and Health Sciences. Montes Claros. BR
  • Dias, Verônica Oliveira; Universidade Estadual de Montes Claros. Center of Biological and Health Sciences. Montes Claros. BR
  • Martelli-Júnior, Hercílio; Universidade José do Rosário Vellano. Center for the Rehabilitation of Craniofacial Anomalies. Alfenas. BR
Braz. j. oral sci ; 15(2): 167-170, Apr.-June 2016. tab
Artigo em Inglês | LILACS, BBO | ID: biblio-848322
ABSTRACT

Aim:

To evaluate the association of environmental risk factors, particularly paternal and maternal age, with gender and type of oral cleft in newborn with nonsyndromic cleft lip with or without cleft palate (NSCL/P).

Methods:

This study included 1,346 children with NSCL/P of two Brazilian Services for treatment of craniofacial deformities. Parental ages were classified into the following groups maternal age <35, 36-39, and ≥40 years; paternal age <39 and ≥40 years. The data was analyzed with chi-square test and multinomial logistic regression analysis. The odds ratios were estimated with a 95% confidence interval.

Results:

Of the 1,346 children included in this study, CLP was the type of NSCL/P with highest prevalence, followed by, respectively, CL and CP. There was a greater occurrence of NSCL/P in males compared to females (55.8% versus 44.2%). CLP was more common in men, while the CL and CP were more prevalent in women (p=0.000). No association between maternal age and clefts was observed (p=0.747). However, there was evidence of association between father's aged ≥40 years old and NSCL/P (p=0.031). When patients with CP were analyzed separately, no association between the father's age and the child's gender (p=0.728) was observed, i.e. the female gender prevails among patients with CP, regardless of the father's age.

Conclusions:

This study showed that there were differences in the distribution of the non-syndromic cleft lip and/or palate and the gender, and fathers aged ≥40 years old may have increased risk of oral cleft. Further studies involving different populations are needed for a better understanding of the effect of maternal and paternal ages as a risk factor for the occurrence of oral clefts (Au)
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Inquéritos e Questionários / Fatores de Risco / Fenda Labial / Fissura Palatina / Idade Materna / Idade Paterna Tipo de estudo: Estudo de etiologia / Fatores de risco Limite: Adulto / Feminino / Humanos / Lactente / Masculino / Recém-Nascido País/Região como assunto: América do Sul / Brasil Idioma: Inglês Revista: Braz. j. oral sci Assunto da revista: Odontologia Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Escola Bahiana de Medicina e Saúde Pública/BR / Universidade Estadual de Campinas/BR / Universidade Estadual de Montes Claros/BR / Universidade José do Rosário Vellano/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Inquéritos e Questionários / Fatores de Risco / Fenda Labial / Fissura Palatina / Idade Materna / Idade Paterna Tipo de estudo: Estudo de etiologia / Fatores de risco Limite: Adulto / Feminino / Humanos / Lactente / Masculino / Recém-Nascido País/Região como assunto: América do Sul / Brasil Idioma: Inglês Revista: Braz. j. oral sci Assunto da revista: Odontologia Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Escola Bahiana de Medicina e Saúde Pública/BR / Universidade Estadual de Campinas/BR / Universidade Estadual de Montes Claros/BR / Universidade José do Rosário Vellano/BR