Glutamine metabolism and its effects on immune response: molecular mechanism and gene expression
Nutrire Rev. Soc. Bras. Aliment. Nutr
;
41: 1-10, Dec. 2016. ilus
Artigo
em Inglês
| LILACS
| ID: biblio-880562
ABSTRACT
This article aims to review glutamine metabolism and its effects on the immune response. Selected topics are addressed, particularly the effect of glutamine on cell survival and proliferation, as well as its importance in some biochemical pathways. The impact of glutamine on muscle, intestine, and liver metabolism are described, and a special section about glutamine regulation of the immune response is included. In this context, the modulation of glutamine on relevant signaling pathways as nuclear factor kappa B (NF-kB), mitogen-activated protein kinases (MAPKs), and heat shock protein and the influence of this amino acid on cell migration and adhesion molecules are highlighted. Some important immune response pathways modulated by glutamine were described as its action incritically ill patients. In summary, this review describes some important actions of glutamine, and a range of reactions and modulatory effects in different organs, which may inform new therapeutic strategies. However, further studies are necessary to provide information about glutamine use, especially about situations in which it can be better used as well as fine-tuning dose and administration.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
NF-kappa B
/
Glutamina
Limite:
Animais
Idioma:
Inglês
Revista:
Nutrire Rev. Soc. Bras. Aliment. Nutr
Assunto da revista:
Ciências da Nutrição
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
University of São Paulo/BR
/
University of São Paulo,/BR
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