Role of vitamin D in insulin resistance in obese individuals
Nutrire Rev. Soc. Bras. Aliment. Nutr
;
42: 2-6, Dec. 2017.
Artigo
em Inglês
| LILACS
| ID: biblio-880874
ABSTRACT
BACKGROUND:
Vitamin D is a fat-soluble compound responsible for promoting intestinal absorption of calcium, and this, in turn, acts as a signal transmitter or activator as protein in secretory processes and release of hormones. VitaminD receptors are distributed in various tissues of the body and involved in biochemical reactions in the pathogenesis of several diseases, such as obesity.OBJECTIVE:
The aim of this article is to provide updated information on the role of vitamin D in insulin resistance inobese individuals.METHODS:
It was conducted a search of articles published in PubMED, SciELO, and LILACS database, without limit forthe year of publication, using the keywords"vitamin D","insulin resistance",and "obesity".RESULTS:
Excess adipose tissue seems to impair insulin signaling by inhibiting the phosphorylation of its receptor, resultingin insulin resistance. Studies have evidenced role of vitamin D in mechanisms involved in the pathogenesis of insulin resistance in obesity by acting in improving glycemic control both by increasing hepatic and peripheral glucoseup take and by promoting the secretion of this hormone.CONCLUSIONS:
Vitamin D exerts a protective effect in the treatment and prevention of insulin resistance in patients with obesity and protects the body against oxidative stress and chronic inflammation, contributing to glycemic control. Unfortunately, current data related to the effects of vitamin D supplementation on insulin resistance are still inconclusive
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vitamina D
/
Resistência à Insulina
/
Obesidade
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Nutrire Rev. Soc. Bras. Aliment. Nutr
Assunto da revista:
Ciências da Nutrição
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Petrônio Portela/BR
/
Universidade Federal da Paraíba/BR
/
Universidade Federal do Piauí/BR
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