Study of the protective effect of dexamethasone on cisplatin-induced ototoxicity in rats
Acta cir. bras
; 32(10): 873-880, Oct. 2017. graf
Article
em En
| LILACS
| ID: biblio-886168
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BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the ability of dexamethasone to protect against cisplatin (CDDP)-induced ototoxicity.Methods:
Male Wistar rats were divided into the following three groups 1) Control (C) 6 animals received intraperitoneal (IP) saline solution, 8 ml/kg/day for four days; 2) C + CDDP 11 animals received 8 ml/kg/day of IP saline and, 90 min after saline administration, 8 mg/kg/day of IP CDDP for four days; and 3) DEXA15 + CDDP 11 animals received IP dexamethasone 15 mg/kg/day and, 90 min after dexamethasone administration, received 8 mg/kg/day of IP CDDP for four days.Results:
It was found that dexamethasone did not protect against weight loss in CDDP-exposed animals. The mortality rate was comparable with that previously reported in the literature. The auditory threshold of animals in the DEXA15 + CDDP group was not significantly altered after exposure to CDDP. The stria vascularis of animals in the DEXA15 + CDDP group was partially preserved after CDDP exposure.Conclusions:
Dexamethasone at the dose of 15 mg/kg/day partially protected against CDDP-induced ototoxicity, based on functional evaluation by brainstem evoked response audiontry (BERA) and morphological evaluation by optical microscopy. However, dexamethasone did not protect against systemic toxicity.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Limiar Auditivo
/
Dexametasona
/
Cisplatino
/
Cóclea
/
Substâncias Protetoras
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2017
Tipo de documento:
Article