Effects of local alendronate administration on bone defect healing. Histomorphometric and radiological evaluation in a rabbit model
Acta cir. bras
;
32(9): 781-795, Sept. 2017. graf
Artigo
em Inglês
| LILACS
| ID: biblio-886237
ABSTRACT
Abstract Purpose:
To performed a histomorphometric and radiological study to evaluate the effects of alendronate sodium administered locally in mandibular bone defects created in rabbits.Methods:
Two circular defects 5 mm in diameter were created bilaterally in the mandibular corpus of 20 New Zealand rabbits (i.e., four defects per animal). Each defect received one of four treatments no treatment (EC group), alendronate irrigation (AL group), autogenous bone grafting (AG group), or alendronate irrigation with autogenous bone grafting (AL+AG group). Histomorphometric and radiological assessments were conducted at 4 and 8 weeks after surgery.Results:
Between-group comparisons of the new bone area, the value of the AL+AG group was significantly lower thanthe remaining three groups at 4 weeks postoperatively. In all groups, the new bone area was significantly larger at 8 weeks than at 4 weeks. The residual graft area at 4 and 8 weeks was significantly higher in the AL+AG group than in the AG group, although it was significantly smaller at 8 weeks than at 4 weeks in both these groups.Conclusion:
The use of alendronate sodium in conjunction with autogenous bone grafting improves the osteoconductive properties of the graft, enhances graft retention in the defect, and improves ossification.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Regeneração Óssea
/
Consolidação da Fratura
/
Alendronato
/
Fraturas Ósseas
/
Conservadores da Densidade Óssea
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Hacettepe University/TR
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