Effects of aquaporin 4 and inward rectifier potassium channel 4 1 on medullospinal edema after methylprednisolone treatment to suppress acute spinal cord injury in rat
Acta cir. bras
;
33(2): 175-184, Feb. 2018. graf
Artigo
em Inglês
| LILACS
| ID: biblio-886262
ABSTRACT
Abstract Purpose: To investigate the effects of aquaporin 4 (AQP4) and inward rectifier potassium channel 4.1 (Kir4.1) on medullospinal edema after treatment with methylprednisolone (MP) to suppress acute spinal cord injury (ASCI) in rats. Methods: Sprague Dawley rats were randomly divided into control, sham, ASCI, and MP-treated ASCI groups. After the induction of ASCI, we injected 30 mg/kg MP via the tail vein at various time points. The Tarlov scoring method was applied to evaluate neurological symptoms, and the wet-dry weights method was applied to measure the water content of the spinal cord. Results: The motor function score of the ASCI group was significantly lower than that of the sham group, and the spinal water content was significantly increased. In addition, the levels of AQP4 and Kir4.1 were significantly increased, as was their degree of coexpression. Compared with that in the ASCI group, the motor function score and the water content were significantly increased in the MP group; in addition, the expression and coexpression of AQP4 and Kir4.1 were significantly reduced. Conclusion: Methylprednisolone inhibited medullospinal edema in rats with acute spinal cord injury, possibly by reducing the coexpression of aquaporin 4 and Kir4.1 in medullospinal tissues.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doenças da Medula Espinal
/
Traumatismos da Medula Espinal
/
Metilprednisolona
/
Canais de Potássio Corretores do Fluxo de Internalização
/
Edema
/
Aquaporina 4
/
Glucocorticoides
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Jilin University/CN
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