Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
An. acad. bras. ciênc
; 89(3): 1369-1379, July-Sept. 2017. tab, graf
Article
em En
| LILACS
| ID: biblio-886755
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Triterpenos
/
Lamiaceae
/
Triterpenos Pentacíclicos
/
Fabaceae
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
An. acad. bras. ciênc
Assunto da revista:
CIENCIA
Ano de publicação:
2017
Tipo de documento:
Article