The relationship between of ACE I/D and the MTHFR C677T polymorphisms in the pathophysiology of type 2 diabetes mellitus in a population of Brazilian obese patients
Arch. endocrinol. metab. (Online)
;
62(1): 21-26, Jan.-Feb. 2018. tab
Artigo
em Inglês
| LILACS
| ID: biblio-887636
ABSTRACT
ABSTRACT Objectives This study aimed to evaluate the frequencies of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) and methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphisms in obese patients with and without type 2 diabetes mellitus (T2DM). Subjects and methods These polymorphisms were analyzed by polymerase chain reaction in 125 patients with obesity, 47 (T2DM) and 78 (Control Group). Results No significant difference was found on comparing the T2DM and Control Groups in respect to the genotypic frequencies of the polymorphisms - (II 13.3% vs. 12.0%; ID 37.8% vs. 37.3; DD 48.9% vs. 50.7%; CC 36.2% vs. 39.0%; CT 46.8% vs. 49.3%; TT 17.0% vs. 11.7%), and alleles (I 32.2% vs. 30.7%; D 67.8% vs. 69.3%; C 59.6% vs. 63.6%; T 40.4% vs. 36.4%) and their synergisms in the pathophysiology of T2DM. On analyzing the T2DM Group, there were no significant differences in the presence of complications. In this population of Brazilian obese patients, no correlation was found between the ACE and MTHFR polymorphisms in the development of T2DM. Conclusion Analyzing only the group with diabetes, there was also no relationship between these polymorphisms and comorbidities.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Polimorfismo Genético
/
Peptidil Dipeptidase A
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
/
Diabetes Mellitus Tipo 2
/
Obesidade
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Arch. endocrinol. metab. (Online)
Assunto da revista:
Endocrinologia
/
Metabolismo
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual Paulista "Júlio de Mesquita Filho"/BR
Similares
MEDLINE
...
LILACS
LIS