Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
Braz. j. med. biol. res
;
50(11): e6455, 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-888957
ABSTRACT
Series of novel coumarin derivatives [I (a-d) and II (a-d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their cytotoxicity, which was tested against SK-LU-1, SPC-A-1 and 95D human lung cancer cell lines, using the MTT assay. The results of this study showed that compounds Ic, Id, IIc, and IId exhibited an efficient percentage of inhibition of cell proliferation.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Cumarínicos
/
Neoplasias Pulmonares
/
Antineoplásicos
Tipo de estudo:
Estudos de avaliação
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Chongqing Cancer Institute/CN
Similares
MEDLINE
...
LILACS
LIS