Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Braz. j. med. biol. res
;
50(12): e6087, 2017. graf
Artigo
em Inglês
| LILACS
| ID: biblio-888963
ABSTRACT
Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-administered with iron dextran in two groups of mice (Fe+DFX and Fe+NAC), and the function of HSPCs was then examined. Iron overload markedly decreased the number of murine HSPCs in bone marrow. Subsequent colony-forming cell assays showed that iron overload also decreased the colony forming capacity of HSPCs, the effect of which could be reversed by DFX and NAC. The bone marrow hematopoiesis damage caused by iron overload could be alleviated by DFX and NAC.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Acetilcisteína
/
Triazóis
/
Benzoatos
/
Células-Tronco Hematopoéticas
/
Quelantes de Ferro
/
Sequestradores de Radicais Livres
/
Sobrecarga de Ferro
/
Substâncias Protetoras
Tipo de estudo:
Estudos de avaliação
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2017
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
China
Instituição/País de afiliação:
Logistics University of People's Armed Police Forces/CN
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