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Safety and efficacy of regional citrate anticoagulation in continuous blood purification treatment of patients with multiple organ dysfunction syndrome
Tuerdi, B; Zuo, L; Sun, H; Wang, K; Wang, Z; Li, G.
  • Tuerdi, B; Xinjiang Medical University. Respiratory Intensive Care Units. Urumqi. CN
  • Zuo, L; Xinjiang Medical University. Respiratory Intensive Care Units. Urumqi. CN
  • Sun, H; Xinjiang Medical University. Respiratory Intensive Care Units. Urumqi. CN
  • Wang, K; Xinjiang Medical University. Respiratory Intensive Care Units. Urumqi. CN
  • Wang, Z; Xinjiang Medical University. Respiratory Intensive Care Units. Urumqi. CN
  • Li, G; Xinjiang Medical University. Respiratory Intensive Care Units. Urumqi. CN
Braz. j. med. biol. res ; 51(1): e6378, 2018. tab
Artigo em Inglês | LILACS | ID: biblio-889003
ABSTRACT
The aim of this study was to discuss the safety and efficacy of regional citrate anticoagulation (RCA) on continuous blood purification (CBP) during the treatment of multiple organ dysfunction syndrome (MODS). Thirty-five patients with MODS were divided into two groups the local citrate anticoagulation (RCA) group, and the heparin-free blood purification (hfBP) group. The MODS severity was assessed according to Marshall's MODS score criteria. Blood coagulation indicators, blood pressure, filter lifespan, filter replacement frequency, anticoagulation indicators, and main metabolic and electrolyte indicators were analyzed and compared between RCA and hfBP groups. RCA resulted in lower blood pressure than hfBP. The filter efficacy in RCA treatment was longer than in the hfBP group. The blood clearance of creatine, blood urea nitrogen and uric acid was better in the RCA group. RCA also led to higher pH than hfBP. Neither treatment resulted in severe bleeding events. In addition, MODS score was positively correlated with prothrombin time and activated partial thromboplastin time but negatively correlated with platelet concentration. RCA is a safer and more effective method in CBP treatment; however, it could also lead to low blood pressure and blood alkalosis.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Hemofiltração / Citratos / Ácido Cítrico / Glucose / Insuficiência de Múltiplos Órgãos / Anticoagulantes Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Xinjiang Medical University/CN

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Hemofiltração / Citratos / Ácido Cítrico / Glucose / Insuficiência de Múltiplos Órgãos / Anticoagulantes Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Xinjiang Medical University/CN