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Efficacy, acceptability, and tolerability of antidepressant treatments for patients with post-stroke depression: a network meta-analysis
Qin, B; Chen, H; Gao, W; Zhao, LB; Zhao, MJ; Qin, HX; Chen, W; Chen, L; Yang, MX.
  • Qin, B; Guangxi University of Science and Technology. Department of Neurology. Affiliated Liuzhou People's Hospital. Liuzhou. CN
  • Chen, H; Guangxi University of Science and Technology. Department of Neurology. Affiliated Liuzhou People's Hospital. Liuzhou. CN
  • Gao, W; Guangxi University of Science and Technology. Department of Neurology. Affiliated Liuzhou People's Hospital. Liuzhou. CN
  • Zhao, LB; Guangxi University of Science and Technology. Department of Neurology. Affiliated Liuzhou People's Hospital. Liuzhou. CN
  • Zhao, MJ; Guangxi University of Science and Technology. Department of Neurology. Affiliated Liuzhou People's Hospital. Liuzhou. CN
  • Qin, HX; Guangxi University of Science and Technology. Department of Neurology. Affiliated Liuzhou People's Hospital. Liuzhou. CN
  • Chen, W; Guangxi University of Science and Technology. Department of Neurology. Affiliated Liuzhou People's Hospital. Liuzhou. CN
  • Chen, L; Guangxi University of Science and Technology. Department of Neurology. Affiliated Liuzhou People's Hospital. Liuzhou. CN
  • Yang, MX; Guangxi University of Science and Technology. Department of Neurology. Affiliated Liuzhou People's Hospital. Liuzhou. CN
Braz. j. med. biol. res ; 51(7): e7218, 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-889121
ABSTRACT
The aim of this study was to investigate the efficacy, acceptability, and tolerability of antidepressants in treating post-stroke depression (PSD) by performing a network meta-analysis of randomized controlled trials of the current literature. Eligible studies were retrieved from online databases, and relevant data were extracted. The primary outcome was efficacy as measured by the mean change in overall depressive symptoms. Secondary outcomes included discontinued treatment for any reason and specifically due to adverse events. Fourteen trials were eligible, which included 949 participants and 9 antidepressant treatments. Few significant differences were found for all outcomes. For the primary outcome, doxepin, paroxetine, and nortriptyline were significantly more effective than a placebo [standardized mean differences −1.93 (95%CI=−3.56 to −0.29), −1.39 (95%CI=−2.59 to −0.21), and −1.25 (95%CI=−2.46 to −0.04), respectively]. Insufficient evidence exists to select a preferred antidepressant for treating patients with post-stroke depression, and our study provides little evidence that paroxetine may be the potential choice when starting treatment for PSD. Future studies with paroxetine and larger sample sizes, multiple medical centers, and sufficient intervention durations is needed for improving the current evidence.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Acidente Vascular Cerebral / Transtorno Depressivo / Antidepressivos Tipo de estudo: Ensaio Clínico Controlado / Revisões Sistemáticas Avaliadas Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Guangxi University of Science and Technology/CN

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Acidente Vascular Cerebral / Transtorno Depressivo / Antidepressivos Tipo de estudo: Ensaio Clínico Controlado / Revisões Sistemáticas Avaliadas Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Guangxi University of Science and Technology/CN