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Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus
Loureiro, Melina Bezerra; Ururahy, Marcela Abbott Galvão; Souza, Karla Simone Costa de; Oliveira, Yonara Monique da Costa; Silva, Heglayne Pereira Vital da; Bortolin, Raul Hernandes; Bezerra, João Felipe; Hirata, Rosario Dominguez Crespo; Maciel-Neto, José Jorge; Arrais, Ricardo Fernando; Almeida, Maria das Graças; Hirata, Mario Hiroyuki; Rezende, Adriana Augusto de.
  • Loureiro, Melina Bezerra; Federal University of Rio Grande do Norte. Department of Clinical and Toxicological Analyses. Natal. BR
  • Ururahy, Marcela Abbott Galvão; Federal University of Rio Grande do Norte. Department of Clinical and Toxicological Analyses. Natal. BR
  • Souza, Karla Simone Costa de; Federal University of Rio Grande do Norte. Department of Clinical and Toxicological Analyses. Natal. BR
  • Oliveira, Yonara Monique da Costa; Federal University of Rio Grande do Norte. Department of Clinical and Toxicological Analyses. Natal. BR
  • Silva, Heglayne Pereira Vital da; Federal University of Rio Grande do Norte. Department of Clinical and Toxicological Analyses. Natal. BR
  • Bortolin, Raul Hernandes; Federal University of Rio Grande do Norte. Department of Clinical and Toxicological Analyses. Natal. BR
  • Bezerra, João Felipe; Federal University of Rio Grande do Norte. Department of Clinical and Toxicological Analyses. Natal. BR
  • Hirata, Rosario Dominguez Crespo; University of São Paulo. Department of Clinical and Toxicological Analyses. São Paulo. BR
  • Maciel-Neto, José Jorge; Federal University of Rio Grande do Norte. Department of Radiology. Natal. BR
  • Arrais, Ricardo Fernando; Federal University of Rio Grande do Norte. Department of Pediatrics. Natal. BR
  • Almeida, Maria das Graças; Federal University of Rio Grande do Norte. Department of Clinical and Toxicological Analyses. Natal. BR
  • Hirata, Mario Hiroyuki; University of São Paulo. Department of Clinical and Toxicological Analyses. São Paulo. BR
  • Rezende, Adriana Augusto de; Federal University of Rio Grande do Norte. Department of Clinical and Toxicological Analyses. Natal. BR
Braz. J. Pharm. Sci. (Online) ; 53(4): e00060, 2017. tab
Artigo em Inglês | LILACS | ID: biblio-889416
ABSTRACT
ABSTRACT The aim of the present study was to investigate the bone mineral density (BMD) of patients with type 1 Diabetes mellitus (T1DM). We also assessed the association between osteoprotegerin (OPG) genetic polymorphisms and BMD. Genotyping was performed for 1181G>C and 163A>G OPG polymorphisms by allelic discrimination in 119 patients with T1DM and 161 normoglycemic (NG) individuals, aged 6 to 20 years old. Glycemic control, serum parameters of bone metabolism and BMD were evaluated. T1DM patients showed low BMD, poor glycemic control and decreased total calcium values when compared to controls (p < 0.05). For all the polymorphisms studied, the genotype and allele frequencies in patients with T1DM were not significantly different from the controls. In patients with T1DM, carriers of OPG 1181CC showed higher concentrations of ionized calcium compared to patients with GG+GC genotypes. These results suggest that low BMD is associated with poor glycemic control in T1DM. Despite the lack of a detected association between OPG polymorphisms and BMD in these patients, the increased ionized calcium in those carrying OPG 1181CC suggests a possible increase in osteoclastogenesis, a conclusion that may be supported by the lower BMD observed in these subjects.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Polimorfismo Genético / Densidade Óssea / Índice Glicêmico / Diabetes Mellitus Tipo 1 Limite: Adolescente / Adulto / Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2017 Tipo de documento: Artigo / Documento de projeto País de afiliação: Brasil Instituição/País de afiliação: Federal University of Rio Grande do Norte/BR / University of São Paulo/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Polimorfismo Genético / Densidade Óssea / Índice Glicêmico / Diabetes Mellitus Tipo 1 Limite: Adolescente / Adulto / Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2017 Tipo de documento: Artigo / Documento de projeto País de afiliação: Brasil Instituição/País de afiliação: Federal University of Rio Grande do Norte/BR / University of São Paulo/BR