Cytotoxic activity in cutaneous leishmaniasis
Mem. Inst. Oswaldo Cruz
;
112(11): 733-740, Nov. 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-894850
ABSTRACT
Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Células Matadoras Naturais
/
Linfócitos T Citotóxicos
/
Leishmaniose Cutânea
/
Linfócitos T CD8-Positivos
/
Citotoxicidade Imunológica
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2017
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal da Bahia/BR
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