Systemic administration of curcumin nanoparticles protects ischemia-reperfusion injury in ovaries: An animal model study
Rev. Assoc. Med. Bras. (1992)
;
64(1): 22-31, Jan. 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-896419
ABSTRACT
Summary Objective:
Ovarian torsion must be diagnosed and treated as early as possible. The aim of the present study was to investigate the effects of intraperitoneal administration of nanocurcumin on ischemia-reperfusion injury in ovaries.Method:
Thirty-five (35) healthy female Wistar rats weighing approximately 250 g were randomized into seven experimental groups (n=5) Group SSG - The rats underwent only laparotomy. Group I A 3-hour ischemia only. Group I/R A 3-hour ischemia and 3-hour reperfusion. Group I/C A 3-hour ischemia only, and 1 mg/kg intraperitoneal administration of curcumin 2.5 hours after induction of ischemia. Group I/R/C A 3-hour ischemia, 3-hour reperfusion, and 1 mg/kg intraperitoneal administration of curcumin 2.5 hours after induction of ischemia. Group I/NC A 3-hour ischemia only and 1 mg/kg intraperitoneal administration of nanocurcumin 2.5 hours after induction of ischemia. Group I/R/C A 3-hour ischemia, 3-hour reperfusion and 1 mg/kg intraperitoneal administration of nanocurcumin 2.5 hours after induction of ischemia.Results:
Nanocurcumin-treated animals showed significantly improved development of ischemia and reperfusion tissue injury compared to those in the other groups (p<0.05). Significant higher values of SOD, tGSH, GPO, GSHRd and GST were observed in I/R/NC animals compared to those in the other groups (p<0.05). The damage indicators (NOS, MDA, MPO and DNA damage level) were significantly lower in I/R/NC animal compared to those of other groups (p<0.05).Conclusion:
Intraperitoneal administration of nanocurcumin can be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ovário
/
Traumatismo por Reperfusão
/
Curcumina
/
Nanopartículas
/
Isquemia
/
Antioxidantes
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Rev. Assoc. Med. Bras. (1992)
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Irã
Instituição/País de afiliação:
Urmia University of Medical Sciences/IR
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