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Ayahuasca: what mental health professionals need to know
Santos, Rafael Guimarães dos; Bouso, José Carlos; Hallak, Jaime Eduardo Cecilio.
  • Santos, Rafael Guimarães dos; University of São Paulo. Ribeirão Preto Medical School. Department of Neurosciences and Behavior. Ribeirão Preto. BR
  • Bouso, José Carlos; University of São Paulo. Ribeirão Preto Medical School. Department of Neurosciences and Behavior. Ribeirão Preto. BR
  • Hallak, Jaime Eduardo Cecilio; University of São Paulo. Ribeirão Preto Medical School. Department of Neurosciences and Behavior. Ribeirão Preto. BR
Arch. Clin. Psychiatry (Impr.) ; 44(4): 103-109, July-Aug. 2017. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-903032
ABSTRACT
Abstract Background Ayahuasca is a psychoactive ethnobotanical concoction that has been used for decades by indigenous groups of the Northwestern Amazon and by syncretic religious organizations for ritual and therapeutic purposes. In the last two decades, it is being used worldwide in evolving practices. Ayahuasca seem to therapeutic effects, but controlled studies are lacking. Moreover, its safety and toxicity are not completely understood. Objectives To present an overview of the effects of ayahuasca based on the most recent human studies. Methods Narrative review. Results Ayahuasca administration in controlled settings appears to be safe from a subjective and physiological perspective, with few adverse reactions being reported. More frequent adverse reactions occur in non-controlled settings. Prolonged psychotic reactions are rare and seem to occur especially in susceptible individuals. Ayahuasca showed antidepressive, anxiolytic, and antiaddictive effects in animal models, observational studies, and in open-label and controlled studies. Discussion Ayahuasca administration in controlled settings appear to be safe. Moreover, ayahuasca seem to have therapeutic effects for treatment-resistant psychiatric disorders that should be further investigated in randomized controlled clinical trials. However, medical complications and cases of prolonged psychotic reactions have been reported, and people with personal or family history of psychotic disorders should avoid ayahuasca intake.


Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Ensaio Clínico Controlado / Estudo observacional / Estudo prognóstico Idioma: Inglês Revista: Arch. Clin. Psychiatry (Impr.) Assunto da revista: Psiquiatria Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: University of São Paulo/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Tipo de estudo: Ensaio Clínico Controlado / Estudo observacional / Estudo prognóstico Idioma: Inglês Revista: Arch. Clin. Psychiatry (Impr.) Assunto da revista: Psiquiatria Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: University of São Paulo/BR