Survival outcome among patients with Ewing's sarcoma of bones and joints: a population-based cohort study
São Paulo med. j
;
136(2): 116-122, Mar.-Apr. 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-904155
ABSTRACT
ABSTRACT BACKGROUND:
The aim here was to elucidate the current survival condition of patients diagnosed with Ewing's sarcoma of the bones and joints and determine independent risk factors associated with the prognosis. DESIGN ANDSETTING:
Retrospective cohort study based on the Surveillance, Epidemiology and End Results (SEER) database in the United States.METHODS:
We identified 397 patients who were diagnosed with Ewing's sarcoma of the bones and joints between January 2004 and December 2013. The multivariate Cox proportional hazards model was used to determine factors associated with the risk of death by adjusting for various factors.RESULTS:
The one, two and five-year disease-specific survival rates were 89.08%, 78.08% and 62.47%, respectively. The factors related to death were age (≥ 18 years versus < 18 years; hazard ratio, HR = 1.77; 95% confidence interval, CI 1.38-2.31); tumor site (extremity versus spine and pelvis; HR = 2.03; 95% CI 1.31-2.62); tumor size (> 10 cm versus ≤ 10 cm; HR = 1.78; 95% CI 1.34-2.56); and type of treatment (surgery alone versus radiotherapy with surgery; HR = 0.51; 95% CI 0.38-0.89; or radiotherapy alone versus radiotherapy with surgery; HR = 1.61; 95% CI 1.10-2.39; or no treatment versus radiotherapy with surgery; HR = 1.86; 95% CI 1.23, 2.58).CONCLUSIONS:
Patients with Ewing's sarcoma showed poor survival in situations of age ≥ 18 years, tumor size > 10 cm, receiving radiotherapy alone and receiving no treatment. Patients undergoing surgery alone had better survival.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Sarcoma de Ewing
/
Neoplasias Ósseas
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adolescente
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
São Paulo med. j
Assunto da revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicina
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Wuhan University/CN
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