Huge recurrent gastric neuroendocrine tumor: a second-line chemotherapeutic dilemma
Autops. Case Rep
;
8(1): e2018005, Jan.-Mar. 2018. ilus
Artigo
em Inglês
| LILACS
| ID: biblio-905466
ABSTRACT
Chemotherapy is considered "state of the art" for the treatment of poorly differentiated neuroendocrine neoplasms. Unfortunately, there is no standard effective post-first-line treatment for relapsing high-grade gastroenteropancreatic neuroendocrine neoplasms. We report the case of a patient with a gastric neuroendocrine carcinoma stage IV, with massive gastrointestinal bleeding at diagnosis. After the first line of platin-based chemotherapy a major tumoral response was documented, but the patient relapsed after 4 months. A second line of chemotherapy treatment was given, with the FOLFOX regimen, and the patient has been free of progression for almost 2 years. There is no second-line standard treatment accepted for this type of carcinoma, but 5-fluorouracil combined with oxaliplatin showed interesting antitumor activity.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Compostos Organoplatínicos
/
Neoplasias Gástricas
/
Carcinoma
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Tumores Neuroendócrinos
/
Fluoruracila
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Autops. Case Rep
Assunto da revista:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Portugal
/
Espanha
Instituição/País de afiliação:
Centro Hospitalar S. Joao/PT
/
Hospital Universitario Ramon y Cajal/ES
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