Histological studies on the retina and cerebellum of Wistar rats treated with ArteetherTM
Braz. j. morphol. sci
;
31(1): 28-32, 1/3/2014. ilus
Artigo
em Inglês
| LILACS
| ID: biblio-911265
ABSTRACT
Introduction:
Arteether TM, a derivative of artemisinin, is among the recent drugs that have given renewed hope for combating malarial menace. The present study investigated the effects of arteetherTM on the histology of the retina and cerebellum of Wistar rats. Materials andMethods:
Twenty adult albino Wistar rats weighing 150-200 g, were randomly divided into four groups (A, B, C and D) of five animals each and used for this study. Group A rats were given intramuscular (i.m.) arteetherTM (3 mg/kg b.w.) daily for 3 days. Group B rats were given i.m. arteetherTM (6 mg/kg b.w.) daily for 3 days. Group C rats were also given i. m. of arteetherTM (3 mg/kg b. w.) daily for 3 days, and the same dose was repeated at two-weekly intervals for 4 further weeks; while Group D rats which received normal saline (0.9 % w/v, 3 ml/kg b.w.), served as controls. At the end of the experiment, the rats were sacrificed by cervical dislocation. The retina and cerebellum were excised and processed routinely for histopathology changes, using haematoxylin and eosin stain (H & E), as well as Nissl stain.Results:
Results obtained showed normal cellular components of the retina and cerebellum in all groups, and no cyto-pathological changes were observed.Conclusion:
Thus, this study showed that under light microscopic examination, therapeutic doses of arteetherTM caused no significant cyto-pathologic changes in the retina and cerebellum of Wistar rats.(AU)
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Retina
/
Cerebelo
/
Artemisininas
/
Malária
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. morphol. sci
Assunto da revista:
Anatomia
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
Nigéria
/
África do Sul
Instituição/País de afiliação:
Obafemi Awolowo University/NG
/
Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria/NG
/
University College Hospital/NG
/
University of KwaZulu-Natal/ZA
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