Correlation among three non-invasive methods (APRI, FIB-4 and Transient elastography) to evaluate liver function and stiffness in patients with viral hepatitis c or schistosomiasis mansoni
Rev. patol. trop
;
47(2): 100-110, jun. 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-913769
ABSTRACT
Both chronic viral hepatitis and schistosomiasis are potentially serious causes of liver fibrosis. Several studies suggest, however, that hepatic fibrosis may be reversible, which highlights the importance, not only of early diagnosis, but, above all, observing this while monitoring the disease. This study aimed to evaluate the correlation between three non-invasive methods for classification of hepatic fibrosis in patients with viral hepatitis or schistosomiasis. The sample consisted of 45 patients with chronic hepatitis with HCV and 17 with schistosomiasis. Medical records were analyzed for data collection related to sex, body mass index (BMI) and laboratory testing for biochemical markers. The evaluation was carried out by means of the following hepatic diagnostic methods:
APRI, FIB-4 and Transient Elastography (Fibroscan), and the subsequent correlation analysis by Spearman test (r). There was a predominance of males among patients with HCV (64.4%). HCV patients also presented the highest average age (54.8 years) and high levels of AST and ALT. Positive correlation was noted between APRI and FIB-4 results in patients of both groups; positive correlation between APRI and Transient Elastography in patients with HCV; and positive correlation between FIB-4 and Elastography in patients with HCV or schistosomiasis. Our data suggest that the non-invasive methods for diagnosis and monitoring of hepatic fibrosis present a high degree of acceptance, especially in patients with HCV.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Esquistossomose mansoni
/
Fibrose
/
Técnicas de Imagem por Elasticidade
/
Hepatite Viral Humana
/
Hepatopatias
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
Rev. patol. trop
Assunto da revista:
Medicina Tropical
/
Patologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Departamento de Medicina, Universidade Federal de Sergipe/BR
/
Laboratório de Imunologia e Biologia Molecular-LIBM, Hospital Universitário - Universidade Federal de Sergipe, Campus da Saúde Prof. João Cardoso Nascimento/BR
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