Clinical features and preventive therapies of radiation-induced xerostomia in head and neck cancer patient: a literature review
Appl. cancer res
;
37: 1-8, 2017. ilus
Artigo
em Inglês
| LILACS, Inca
| ID: biblio-915109
ABSTRACT
Xerostomia or dry mouth is one of the most common and disturbing adverse effects following radiotherapy for head and neck cancer (HNC). This complication strongly increases the risk for dental caries, difficulties with chewing, swallowing and sleep disorders with significant impact on patients' quality of life. Current treatment approaches of xerostomia are often difficult and bring in many cases no substantial relief for the patient. This paper discusses the clinical features and current knowledge of xerostomia prevention in order to evaluate the real possibilities of reducing the incidence and severity of this complication in HNC patients. Salivary gland cytoprotectants (amifostine), muscarinic agonist stimulation (pilocarpine and bethanechol), salivary gland-sparing radiation technique (intensity-modulated radiotherapy- IMRT), surgical relocation of the submandibular gland, intraoral stent and stem cell transplantation are promising techniques that are discussed in this study (AU)
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pilocarpina
/
Radioterapia
/
Glândulas Salivares
/
Glândula Submandibular
/
Literatura de Revisão como Assunto
/
Transplante de Células-Tronco
/
Prevenção de Doenças
/
Neoplasias de Cabeça e Pescoço
Tipo de estudo:
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Inglês
Revista:
Appl. cancer res
Assunto da revista:
Neoplasias
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
A.C.Camargo Cancer Center/BR
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