Current challenges in the therapeutic use of induced pluripotent stem cells (iPSCs) in cancer therapy
Appl. cancer res
;
37: 1-8, 2017. ilus
Artigo
em Inglês
| LILACS, Inca
| ID: biblio-915112
ABSTRACT
Induced Pluripotent Stem Cells (iPSCs) technology has catapulted the field of stem-cell biology through ectopic expression of reprogramming factors. Ever since its discovery, the potential of iPSCs has been explored by many scientists to unravel the molecular mechanism responsible for cancer initiation and progression. Besides modeling cancer, the further applications of this technology includes high-throughput drug screening, epigenetic reprogramming of cancer cell state to normal, immunotherapy and regenerative cell therapies. Here, we review the current challenges on clinical applications of iPSCs with respect to understanding cancer and personalizing treatment for the disease (AU)
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Células-Tronco
/
Células-Tronco Pluripotentes
/
Mecanismos Moleculares de Ação Farmacológica
/
Neoplasias
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Appl. cancer res
Assunto da revista:
Neoplasias
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Índia
Instituição/País de afiliação:
Jaslok Hospital & Research Centre/IN
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