The therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in rats
Acta cir. bras
;
33(6): 499-507, June 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-949358
ABSTRACT
Abstract Purpose:
To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects.Methods:
A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group.Results:
Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin.Conclusion:
Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Útero
/
Capsaicina
/
Antineoplásicos Alquilantes
/
Curcumina
/
Ciclofosfamida
/
Antioxidantes
Tipo de estudo:
Estudos de avaliação
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Elbistan State Hospital/TR
/
Inonu University/TR
/
Pamukkale University/TR
Similares
MEDLINE
...
LILACS
LIS