Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
Biol. Res
;
47: 1-8, 2014. graf
Artigo
em Inglês
| LILACS
| ID: biblio-950770
ABSTRACT
BACKGROUND:
Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption, nitric oxide (NO) synthesis, ATPase activity and lipid oxidation in mitochondria isolated from liver and kidneys of diabetic db/db mice.RESULTS:
Hyperglycaemia increased oxygen consumption and decreased NO synthesis in liver mitochondria isolated from diabetic mice relative to the control mice. In kidney mitochondria, hyperglycaemia increased state 3 oxygen consumption and thiobarbituric acid-reactive substances (TBARS) levels in diabetic mice relative to control mice. Interestingly, treating db/db mice with curcumin improved or restored these parameters to normal levels; also curcumin increased liver mitochondrial ATPase activity in db/db mice relative to untreated db/db mice.CONCLUSIONS:
These findings suggest that hyperglycaemia modifies oxygen consumption rate, NO synthesis and increases TBARS levels in mitochondria from the liver and kidneys of diabetic mice, whereas curcumin may have a protective role against these alterations.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Peroxidação de Lipídeos
/
Curcumina
/
Diabetes Mellitus Tipo 2
/
Rim
/
Fígado
/
Mitocôndrias
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Universidad Michoacana de San Nicolás de Hidalgo/MX
/
Universidad de Guanajuato/MX
Similares
MEDLINE
...
LILACS
LIS