Genetic variants associated with neurodegenerative Alzheimer disease in natural models
Biol. Res
;
49: 1-9, 2016. graf, tab
Artigo
em Inglês
| LILACS
| ID: biblio-950841
ABSTRACT
The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Variação Genética
/
Modelos Animais de Doenças
/
Doença de Alzheimer
Tipo de estudo:
Fatores de risco
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Universidad de Valparaiso/CL
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