In vitro chemokine (C-C motif) receptor 6-dependent non-inflammatory chemotaxis during spermatogenesis
Biol. Res
;
51: 12, 2018. graf
Artigo
em Inglês
| LILACS
| ID: biblio-950898
ABSTRACT
BACKGROUND:
Chemokine (C-C motif) receptor 6 (CCR6) is present in sperm and plays a significant role in sperm motility and chemotaxis acting in the reproductive tracts. However, the expression and functional significance of CCR6 in testis are still poorly understood, especially in the process of spermatogenesis. METHODS ANDRESULTS:
CCR6 was expressed in spermatogenic cell lines and its expression was shown in an age-dependent upregulation manner from puberty to adulthood in mouse testis. Immunostaining results confirmed the localization of CCR 6 in testis. Further chemotaxis assays demonstrated that spermatogenic cells GC-1 and -2 exhibited a directional movement toward CCR6-specific ligand such as CCL20 or Sertoli cells in vitro.CONCLUSIONS:
The present findings indicate that CCR6 is involved in the chemotaxis of spermatogenic cells in vitro and promotes chemotaxis under non-inflammatory conditions during normal spermatogenesis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Espermatogênese
/
Quimiotaxia
/
Criptorquidismo
/
Quimiocina CCL20
/
Receptores CCR6
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Peking University Shenzhen Hospital/CN
/
Shenzhen University School of Medicine/CN
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