Prevalence of Guillain-Barré syndrome among Zika virus infected cases: a systematic review and meta-analysis
Braz. j. infect. dis
;
22(2): 137-141, Mar.-Apr. 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-951630
ABSTRACT
ABSTRACT Zika virus (ZIKV) is an emergent flavivirus transmitted mainly through Aedes spp. mosquitoes that is posing challenge to healthcare services in countries experiencing an outbreak. Usually ZIKV infection is mild, but in some cases it has been reported to progress into neurological diseases such as microcephaly in infants and Guillain-Barré syndrome (GBS) in adults. GBS is a debilitating autoimmune disorder that affects peripheral nerves. Since ZIKV caused massive outbreaks in South America in the past few years, we aimed to systematically review the literature and perform a meta-analysis to estimate the prevalence of GBS among ZIKV-infected individuals. We searched PubMed and Cochrane databases and selected three studies for a meta-analysis. We estimated the prevalence of ZIKV-associated GBS to be 1.23% (95% CI = 1.17-1.29%). Limitations include paucity of data regarding previous flavivirus infections and ZIKV-infection confirmation issues. Our estimate seems to be low, but cannot be ignored, since ZIKV outbreaks affects an overwhelming number of individuals and GBS is a life-threatening debilitating condition, especially in pregnant women. ZIKV infection cases must be closely followed to assure prompt care to reduce the impact of GBS associated-sequelae on the quality of life of those affected.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Surtos de Doenças
/
Síndrome de Guillain-Barré
/
Zika virus
/
Infecção por Zika virus
Tipo de estudo:
Estudo de prevalência
/
Fatores de risco
/
Revisões Sistemáticas Avaliadas
Limite:
Feminino
/
Humanos
/
Gravidez
País/Região como assunto:
América Central
/
América do Sul
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Itália
/
Reino Unido
Instituição/País de afiliação:
King's College London/GB
/
Scientific Institute for Research, Hospitalization and Care/IT
/
Universidade Federal de Pernambuco/BR
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