Your browser doesn't support javascript.
loading
Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy
Zhang, F; Bao, Z J; Shi, D M; Xiang, P; Xiao, L; Huang, Y Q; Zhang, G S; Yin, S M.
  • Zhang, F; Fudan University. Division of Gastroenterology. Shanghai Medical College. Huadong Hospital. Shanghai. CN
  • Bao, Z J; Fudan University. Division of Gastroenterology. Shanghai Medical College. Huadong Hospital. Shanghai. CN
  • Shi, D M; Fudan University. Division of Gastroenterology. Shanghai Medical College. Huadong Hospital. Shanghai. CN
  • Xiang, P; Fudan University. Division of Gastroenterology. Shanghai Medical College. Huadong Hospital. Shanghai. CN
  • Xiao, L; Fudan University. Division of Gastroenterology. Shanghai Medical College. Huadong Hospital. Shanghai. CN
  • Huang, Y Q; Fudan University. Division of Gastroenterology. Shanghai Medical College. Huadong Hospital. Shanghai. CN
  • Zhang, G S; Fudan University. Division of Gastroenterology. Shanghai Medical College. Huadong Hospital. Shanghai. CN
  • Yin, S M; Fudan University. Division of Gastroenterology. Shanghai Medical College. Huadong Hospital. Shanghai. CN
Braz. j. med. biol. res ; 49(2): e5080, 2016. tab, graf
Artigo em Inglês | LILACS | ID: biblio-951656
ABSTRACT
We aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-positive patients who met the treatment indication (controls). The GS group was divided into GS group 1 and GS group 2. All groups were administered bismuth potassium citrate (220 mg), esomeprazole (20 mg), amoxicillin (1.0 g), and furazolidone (100 mg) twice daily for 14 days. GS group 1 maintained a left lateral horizontal position for 30 min after dosing. H. pylori was detected using rapid urease testing and histologic examination of gastric mucosa before and 3 months after therapy. Mucosal histologic manifestations were evaluated using visual analog scales of the updated Sydney System. GS group 1 had a higher prevalence of eradication than the GS group 2 (intention-to-treat [ITT] P=0.025; per-protocol [PP] P=0.030), and the control group had a similar prevalence. GS group 2 had a lower prevalence of eradication than controls (ITT P=0.006; PP P=0.626). Scores for chronic inflammation and activity declined significantly (P<0.001) 3 months after treatment, whereas those for atrophy and intestinal metaplasia showed no significant change. Prevalence of adverse reactions was similar among groups during therapy (P=0.939). A bismuth-containing quadruple therapy regimen plus postural change after dosing appears to be a relatively safe, effective, economical, and practical method for H. pylori eradication in gastrectomized patients.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Helicobacter pylori / Infecções por Helicobacter / Coto Gástrico / Gastrectomia / Antibacterianos Tipo de estudo: Ensaio Clínico Controlado / Guia de Prática Clínica / Fatores de risco Limite: Adulto / Idoso / Aged80 / Humanos / Masculino Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Fudan University/CN

Similares

MEDLINE

...
LILACS

LIS


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Helicobacter pylori / Infecções por Helicobacter / Coto Gástrico / Gastrectomia / Antibacterianos Tipo de estudo: Ensaio Clínico Controlado / Guia de Prática Clínica / Fatores de risco Limite: Adulto / Idoso / Aged80 / Humanos / Masculino Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Fudan University/CN