Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells
Braz. j. med. biol. res
;
50(7): e6390, 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-951701
ABSTRACT
Using two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II))-coordination compounds, namely, Py3CoL1 (1) and Py3CoL2 (2) (Py=pyridine, L1=3,5-ClC6H2(O)C=NC6H3(O)-4-NO2, L2=3,5-BrC6H2(O)C=NC6H3(O)-4-NO2) have been synthesized under solvothermal conditions. Single crystal X-ray structural analysis revealed that compounds 1 and 2 are both six-coordinate in a distorted octahedral geometry, and the 1D chain structure was formed by the π…π and C-H…O interactions or C-H…Cl interaction. The in vitro antitumor activities of 1, 2 and their corresponding organic ligands Py, L1, and L2 were studied and evaluated, in which three human skin cancer cell lines (A-431, HT-144 and SK-MEL-30) were used in the screening tests.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Bases de Schiff
/
Neoplasias Cutâneas
/
Cobalto
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Chongqing Hospital of Traditional Chinese Medicine/CN
/
Southern Medical University/CN
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