The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats
Braz. J. Pharm. Sci. (Online)
;
54(1): e17442, 2018. graf
Artigo
em Inglês
| LILACS
| ID: biblio-951917
ABSTRACT
Abstract The present study was performed to explore the curative effect of Methylsulfonylmethane (MSM) in an experimental model of myoglobinuric acute renal failure (ARF). In this experimental model, Rats were injected with 50% glycerol (10 mL/kg, im) followed by an hour later and daily in the next six days by MSM (400 mg/kg) or saline. Kidney's function (urea and creatinine), and reduced glutathione were analyzed. A renal failure produced by glycerol injection, with a significant increase of blood urea and serum creatinine was observed. Rats that received MSM in addition to glycerol had significantly lower blood urea and serum creatinine levels compared to those receiving glycerol alone. However, glutathione has markedly increased after MSM treatment. The effect is probably due to the antioxidant activity of MSM. This may provide therapeutic opportunities for treating humans, myoglobinuric ARF.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Compostos de Enxofre
/
Mecanismos Defensivos e Curativos
/
Insuficiência Renal
/
Glicerol
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. J. Pharm. Sci. (Online)
Assunto da revista:
Farmacologia
/
Teraputica
/
Toxicologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Síria
Instituição/País de afiliação:
Damascus University/SY
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