Effective method for the detection of piroxicam in human plasma using HPLC
Braz. oral res. (Online)
;
30(1): e58, 2016. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-952014
ABSTRACT
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by the general population to alleviate inflammation and pain after oral surgeries. Piroxicam is among the most commonly used NSAIDs and excels in controlling pain, swelling, trismus and other common symptoms of inflammation. This study aimed to evaluate different concentrations of piroxicam and its major metabolite, 5'-hydroxypiroxicam, in human plasma samples over time using high performance liquid chromatography (HPLC) after liquid-liquid extraction. Briefly, 10 volunteers participated in this study after approval by the Ethics Committee of Bauru School of Dentistry, Universidade de São Paulo - USP, Brazil. Volunteers received a single dose oral of piroxicam (20 mg) and had blood collected at various times following an established protocol. The methodology of liquid-liquid extraction was effective for determining concentrations of piroxicam in plasma using HPLC in 10 out of 10 volunteers while 5'-hydroxypiroxicam was only detected in 2 out of 10 volunteers.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Piroxicam
/
Anti-Inflamatórios não Esteroides
/
Cromatografia Líquida de Alta Pressão
/
Extração Líquido-Líquido
Tipo de estudo:
Estudo diagnóstico
/
Estudos de avaliação
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. oral res. (Online)
Assunto da revista:
Odontologia
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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