Is preoperative clopidogrel resistance a predictor of bleeding and risks in patients undergoing emergency cabg surgery?
Rev. bras. cir. cardiovasc
;
33(4): 330-338, July-Aug. 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-958435
ABSTRACT
Abstract Objective:
The aims of this study were to determine whether the detection of preoperative clopidogrel resistance in patients undergoing cardiac surgery while using clopidogrel could play a guiding role in the prediction of postoperative excessive bleeding, transfusion requirements, and risks and to provide clinically significant data.Methods:
Two hundred and twenty-two patients [median age 59.4 (38-83) years; 38 females] undergoing emergency and elective coronary artery bypass graft (CABG) surgeries in our clinic were evaluated prospectively. Patients with multiple systemic diseases, other than diabetes mellitus (DM) and hypertension (HT), were excluded. Patients receiving clopidogrel were also evaluated for clopidogrel resistance and grouped according to the results of this test. Assessments of platelet functions were performed by multiplate impedance aggregometry method and adenosine diphosphate test.Results:
The use of postoperative fresh blood replacement and platelet transfusion was higher in patients receiving clopidogrel than in those not receiving it (P=0.001, P=0.018). DM, HT, myocardial infarction, and the number of presentation to the emergency room were significantly higher in patients receiving clopidogrel than in those not receiving it (P<0.05). No significant difference was determined between patients with and without clopidogrel resistance regarding the amount of bleeding during and after surgery, erythrocyte suspension and fresh-frozen plasma transfusion rates, preoperative troponin values, ejection fraction values, and length of hospital stays (P>0.05).Conclusion:
We think that resistance studies in patients receiving clopidogrel before cardiac surgery are not efficient to predict bleeding and bleeding-related complications in patients undergoing emergency and elective CABG surgeries.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Resistência a Medicamentos
/
Inibidores da Agregação Plaquetária
/
Ponte de Artéria Coronária
/
Hemorragia Pós-Operatória
/
Clopidogrel
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudos de avaliação
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. bras. cir. cardiovasc
Assunto da revista:
Cardiologia
/
Cirurgia Geral
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
University of Health Sciences/TR
Similares
MEDLINE
...
LILACS
LIS