XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia
Arch. Clin. Psychiatry (Impr.)
;
45(3): 53-56, May-June 2018. tab, graf
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-961982
ABSTRACT
Abstract Background: Oxidative stress induced DNA damage has been assumed to contribute to the etiopathogenesis of schizophrenia (Sch). Smoking prevalence was more common in patients with Sch. The X-ray repair cross-complementation group 4 (XRCC4) gene plays an important role in the repair of DNA double-strand breaks. Objective: The purpose of this study was to investigate whether XRCC4 rs6869366 polymorphism has a relationship both in nicotine dependence (ND) and Sch+ND risk. Methods: One hundred and four patients with Sch+ND, 133 subjects with ND only and 70 healthy controls were enrolled in the study. XRCC4 rs6869366 polymorphism was analyzed using PCR-RFLP assay. Results: The frequency of XRCC4 rs6869366 GG genotype was more common in the ND and Sch+ND group than controls (p = 0.001 and p = 0.001, respectively). XRCC4 rs6869366 TT genotype was lower in both ND and Sch+ND group compared to controls (p = 0.001 and p = 0.001, respectively). Also, XRCC4 rs6869366 G allele was higher in Sch+ND group than controls (p = 0.001) while XRCC4 rs6869366 T allele was lower in ND group than healthy controls (p=0.001). XRCC4 rs6869366 GT genotype was lower in ND group than control group (p = 0.003). Discussion: These results suggested that the XRCC4 rs6869366 polymorphism G related genotype/allele was associated with susceptibility to both ND and Sch+ND in a Turkish population.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Fatores de risco
Idioma:
Inglês
Revista:
Arch. Clin. Psychiatry (Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery/TR
/
Gaziantep Univesity/TR
/
Hitit University/TR
/
Istanbul University/TR
/
Yedikule Hospital for Chest Diseases and Thoracic Surgery Training and Research Hospital/TR
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