Fatal case of donor-derived colistin-resistant carbapenemase-producing Klebsiella pneumoniae transmission in cardiac transplantation
Braz. j. infect. dis
;
22(3): 235-238, May-June 2018. graf
Artigo
em Inglês
| LILACS, SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-974217
ABSTRACT
ABSTRACT Herein we report a fatal case of donor-derived transmission of XDR-resistant carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) in cardiac transplantation. A 59-year-old male patient with non-obstructive hypertrophic cardiomyopathy underwent heart transplantation. On day 5 post-operation, blood cultures from the donor were positive for colistin-resistant carbapenemase-producing K. pneumoniae (ColR KPC-Kp) susceptible only to amikacin. Recipient blood cultures were also positive for ColR KPC-Kp with the same sensitivity profile as the donor isolate with an identical PFGE pattern. The patient was treated with double-carbapenems and amikacin. The patient evolved to pericarditis, osteomyelitis, and pulmonary necrosis, all fragment cultures positive for the same agent. The patient developed septic shock, multiple organ failure and died on day 50 post-transplantation. Based on current microbiological scenario worldwide the possibility of transmitting multidrug resistant (MDR) organisms should be considered.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doadores de Tecidos
/
Infecções por Klebsiella
/
Transplante de Coração
/
Transplantados
/
Enterobacteriáceas Resistentes a Carbapenêmicos
/
Klebsiella pneumoniae
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Associação Fundo de Incentivo a Pesquisa - AFIP/BR
/
Instituto Dante Pazzanese de Cardiologia/BR
/
Universidade Federal de São Paulo/BR
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