NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/ß-catenin signaling pathway
Braz. j. med. biol. res
;
52(1): e7952, 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-974269
ABSTRACT
Malignant melanoma is an aggressive skin cancer with a high mortality rate. Nucleolar protein 14 (NOP14) has been implicated in cancer development. However, the role of NOP14 in malignant melanoma progression remains largely unclear. In this study, we observed that malignant melanoma tissue showed NOP14 down-regulation compared to melanocytic nevi tissues. Moreover, we observed that NOP14 expression was significantly associated with melanoma tumor thickness and lymph node metastasis. NOP14 overexpression in melanoma cells suppressed proliferation, caused G1 phase arrest, promoted apoptosis, and inhibited melanoma cell migration and invasion. Further investigations revealed that NOP14 overexpression reduced the expression levels of Wnt3a, β-catenin, and GSK-3β of the Wnt/β-catenin pathway. In summary, we demonstrated that NOP14 inhibited melanoma cell proliferation and metastasis by regulating the Wnt/β-catenin signaling pathway.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Neoplasias Cutâneas
/
Proteínas Nucleares
/
Beta Catenina
/
Via de Sinalização Wnt
/
Melanoma
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Affiliated Hospital of Jinan University/CN
/
Guangzhou First People's Hospital, School of Medicine, South China University of Technology/CN
/
Guangzhou Institute of Dermatology/CN
Similares
MEDLINE
...
LILACS
LIS