Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocin
Braz. J. Pharm. Sci. (Online)
;
54(3): e17669, 2018. graf, ilus
Artigo
em Inglês
| LILACS
| ID: biblio-974396
ABSTRACT
Olanzapine and risperidone are widely prescribed atypical antipsychotics used in the treatment of schizophrenia and various other psychiatric disorders. Both of these drugs have been extensively reported to cause Type 2 diabetes mellitus and pancreatitis, however, the mechanism of olanzapine and risperidone-induced toxicity has not been so far unveiled. We, therefore, compared the streptozocin-induced pancreatic damage with that of pancreas isolated from olanzapine and risperidone treated rats. It was noticed that fibrotic growth, necrosis and derangement of the pancreatic islet cells caused by streptozocin were more pronounced than olanzapine and risperidone.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pâncreas
/
Benchmarking
Idioma:
Inglês
Revista:
Braz. J. Pharm. Sci. (Online)
Assunto da revista:
Farmacologia
/
Teraputica
/
Toxicologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Paquistão
Instituição/País de afiliação:
Khyber Teaching Hospital+PK
/
University of Peshawar/PK
/
University of Swabi/PK
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