An unfavorable intrauterine environment may determine renal functional capacity in adulthood: a meta-analysis
Clinics
; 73: e401, 2018. tab, graf
Article
em En
| LILACS
| ID: biblio-974909
Biblioteca responsável:
BR1.1
ABSTRACT
Since studies show that an unfavorable environment during intrauterine development predisposes individuals to several diseases in adulthood, our objective is to assess the relation between fetal growth restriction and chronic renal disease in adults. We searched four different electronic databases through November 2017 CENTRAL, EMBASE, LILACS and MEDLINE. We selected studies with longitudinal or transversal designs associating kidney function in adulthood with low birth weight. Two reviewers evaluated the inclusion criteria and the risk of bias and extracted data from the included papers. Thirteen studies were selected for the systematic review and meta-analysis. We observed increased risks of presenting end-stage renal disease (risk ratio 1.31, 95% confidence interval 1.17, 1.47), a lower glomerular filtration rate (ml/min) (mean difference 7.14; 95% confidence interval -12.12, -2.16), microalbuminuria (risk ratio 1.40; 95% confidence interval 1.28, 1.52) and a small increase in the albumin/creatinine ratio (mean difference 0.46; 95% confidence interval 0.03, 0.90) in the low birth weight patients, compared with control group. These findings suggest that low birth weight is associated with renal dysfunction in adults.
Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Insuficiência Renal Crônica
/
Retardo do Crescimento Fetal
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Clinics
Assunto da revista:
MEDICINA
Ano de publicação:
2018
Tipo de documento:
Article