Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state
Mem. Inst. Oswaldo Cruz
;
113(11): e180320, 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-976230
ABSTRACT
BACKGROUND The first dengue cases in Brazil with laboratory confirmation occurred in the northern region of the country, with the isolation of two serotypes, dengue virus 1 (DENV-1) and DENV-4. In Ceará, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolations. OBJECTIVES The aim of this study was to characterise the first DENV-4 epidemic in the state of Ceará, Brazil. METHODS The study population was composed of patients with suspected dengue that were reported to health care units from January to December 2012. The laboratory confirmation of infection was made by viral isolation, reverse transcription polymerase chain reaction (RT-PCR), AgNS1, immunohistochemistry and IgM enzyme-linked immunosorbent assay (ELISA). MAIN CONCLUSIONS In the study year, 72,211 suspected dengue cases were reported and 51,865 of these cases (71.8%) were confirmed to be positive. Co-circulation of three serotypes, DENV-1, DENV-3 and DENV-4, was detected with a predominance of DENV-4 (95.3%). Most cases were not severe, but there were 44 fatal outcomes. DENV-4 Genotype II was identified for the first time in Ceará.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Causas de Morte
/
Dengue
Tipo de estudo:
Estudo de etiologia
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Centro Universitário Christus/BR
/
Instituto Oswaldo Cruz-Fiocruz/BR
/
Instituto de Prevenção de Câncer/BR
/
Laboratório Central de Saúde Pública/BR
/
Secretaria de Saúde do Estado do Ceará/BR
/
Universidade Estadual do Ceará/BR
/
Universidade Federal do Ceará/BR
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