Muerte súbita en epilepsia / Sudden death in epilepsy
Rev. méd. Chile
;
146(8): 902-908, ago. 2018. tab
Artigo
em Espanhol
| LILACS
| ID: biblio-978773
ABSTRACT
The risk of sudden unexpected death in patients with epilepsy (SUDEP), is 20 to 25 times greater than in the general population. This increased risk is seen specially in refractory epilepsy, with an incidence of 9:1,000 patients-years. Risk factors have been established based on retrospective studies, finding that the frequency of seizures, specially generalized tonic clonic seizures, is the most important one. The physiopathological mechanism of SUDEP is not yet fully understood. Autonomic system abnormalities, as well as cardiac and respiratory changes have been found. The finding of new molecular biomarkers to identify patients with increased risk should be a priority. Treatment is based in the management of risk factors, although clear recommendations are hard to establish given the low level of evidence.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Morte Súbita
/
Epilepsia
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Clínica Universidad de los Andes/CL
/
Universidad de Los Andes/CL
/
Universidad del Desarrollo/CL
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