Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena / Association of the FTO (rs9939609) genotype with energy intake
Rev. méd. Chile
;
146(11): 1252-1260, nov. 2018. tab, graf
Artigo
em Espanhol
| LILACS
| ID: biblio-985698
RESUMEN
Background:
Fat-mass-associated-gene (FTO) is associated with higher energy intake and specific food preferences.Aim:
To investigate the association of the FTO genotype with energy intake, macronutrient and alcohol consumption. Material andMethods:
Four hundred and nine participants of the GENADIO (Genes, Environment, Diabetes and Obesity) study were included. Energy intake, macronutrient and alcohol consumption were the outcomes of interest. The association of FTO (rs9939609) genotype with these outcomes was investigated using linear regression analyses, adjusting for confounding variables.Results:
After adjusting for socio-demographic factors, being a carrier of the risk allele for the FTO gene was associated with a higher energy intake (173 kcal per each extra copy of the risk variant [95% confidence intervals (CI) 45; 301], (P = 0.008). After adjusting for lifestyle factors and body mass index, the association was slightly attenuated but remained significant (144 kcal [95% CI 14; 274], p = 0.030).Conclusions:
The FTO genotype is associated with a higher energy intake.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ingestão de Energia
/
Consumo de Bebidas Alcoólicas
/
Nutrientes
/
Dioxigenase FTO Dependente de alfa-Cetoglutarato
/
Genótipo
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Chile
/
Reino Unido
Instituição/País de afiliação:
Pontificia Universidad Católica de Chile/CL
/
Universidad Católica de la Santísima Concepción/CL
/
Universidad de Chile/CL
/
Universidad de Concepción/CL
/
University of Glasgow/GB
Similares
MEDLINE
...
LILACS
LIS