Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Acta cir. bras
;
34(3): e201900305, 2019. graf
Artigo
em Inglês
| LILACS
| ID: biblio-989062
ABSTRACT
Abstract Purpose:
To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).Methods:
The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats.Results:
EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue.Conclusion:
This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Neoplasias Gástricas
/
Extratos Vegetais
/
Adenocarcinoma
/
Usnea
/
Acetatos
/
Antineoplásicos Fitogênicos
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Ataturk University/TR
/
Erzincan Binali Yildirim University/TR
/
Recep Tayyip Erdogan University/TR
/
Selcuk University/TR
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