Diagnostic performance of qfr for the evaluation of intermediate coronary artery stenosis confirmed by fractional flow reserve
Rev. bras. cir. cardiovasc
;
34(2): 165-172, Mar.-Apr. 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-990563
ABSTRACT
Abstract Introduction:
Quantitative flow ratio (QFR) is a novel method enabling efficient computation of FFR from three-dimensional quantitative coronary angiography (3D QCA) and thrombolysis in myocardial infarction (TIMI) frame counting. We decided to perform a systematic review and quantitative meta-analysis of the literature to determine the correlation between the diagnosis of functionally significant stenosis obtained by QFR versus FFR and to determine the diagnostic accuracy of QFR for intermediate coronary artery stenosis.Methods:
We searched PubMed, Embase, and Web of Science for studies concerning the diagnostic performance of QFR. Our meta-analysis was performed using the DerSimonian and Laird random effects model to determine sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR-), and diagnostic odds ratio (DOR). The sROC was used to determine diagnostic test accuracy.Results:
Nine studies consisting of 1175 vessels in 1047 patients were included in our study. The pooled sensitivity, specificity, LR+, LR-, and DOR for QFR were 0.89 (95% CI 0.86-0.92), 0.88 (95% CI 0.86-0.91), 6.86 (95% CI, 5.22-9.02), 0.14 (95% CI 0.10-0.21), and 53.05 (95% CI 29.75-94.58), respectively. The area under the summary receiver operating characteristic (sROC) curve for QFR was 0.94.Conclusion:
QFR is a simple, useful, and noninvasive modality for diagnosis of functional significance of intermediate coronary artery stenosis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Angiografia Coronária
/
Estenose Coronária
/
Reserva Fracionada de Fluxo Miocárdico
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. cir. cardiovasc
Assunto da revista:
Cardiologia
/
Cirurgia Geral
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Second Xiangya Hospital/CN
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