Splicing isoform-specific functional genomic in cancer cells
Appl. cancer res
;
38: 1-18, jan. 30, 2018. tab., ilus
Artigo
em Inglês
| LILACS, Inca
| ID: biblio-994739
ABSTRACT
Alternative splicing is a regulated process whereby one gene can generate multiple mRNA isoforms susceptible to be translated into protein isoforms of various functions. Several publications report the aberrant expression of splicing isoforms in cancer cells and tissues. However, in most cases, their function remains to be established. In this review article, I will discuss the molecular tool available to perform isoform-specific functional genomics, the methodologies to quantify their effectiveness and the resulting isoform-specific phenotype in human cancer cell lines (AU)
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Carcinógenos
/
Isoformas de Proteínas
/
Genômica
/
Fatores de Processamento de RNA
Limite:
Humanos
Idioma:
Inglês
Revista:
Appl. cancer res
Assunto da revista:
Neoplasias
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
University of Texas Southwestern Medical/US
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