[ comparative study on results of anemia treatment between peritoneal dialysis and hemodialysis patients]

ABSTRACT

Anemia is one of the most serious complications in patients under dialysis. The aim of this study was to investigate the influence of haemodialysis and continuous ambulatory peritoneal dialysis on anaemia during the first six months of treatment by Erythropoentin. This cross - sectional descriptive study was done in Dialysis Center of Imam Reza Hospital in the year 2005. 53 patients on haemodialysis and 47 patients on CAPD were analyzed. They received low doses of erythropoietin ranging from 50 U/Kg/wk to 100 U/Kg/wk. The EPO dose/week, hemoglobin, ferritin, transferrin saturation [TS], albumin and intact parathyroid hormone [iPTH] were analyzed befor and six months after study. Erythropoetin treatment was prescribed if HB < 11. Individual and laboratory data were gatherd in a questionnaire and analyzed by descriptive statistics and frequency distribution tables. In the CAPD group, the mean hemoglobin level increased from 8.7 +/- 0.2 to 10.87 +/- 1.67 g/dl [P < 0.001] and hematocrit from 25.3 +/- 1.0 to 32.76 +/- 4.92% [P < 0.001], while in the HD group the mean hemoglobin rose from 8.7 +/- 0.6 to 9.25 +/- 1.8 g/dl [P < 0.001] and Hct from 25.7 +/- 2.3 to 28.07 +/- 6.22% [P < 0.001]. The CAPD group needed a significantly lower weekly dosage of erythropoietin than HD group [72 -/+ 18 U/Kg/wk vs. 92 -/+ 8 U/kg, p < 0.01]. At the end of the study TS was similar in both groups, while ferritin was higher in HD patients, with a higher percentage of HD patients using intravenous iron [HD 77% vs. PD 49%, p=0.001]. Serum albumin and iPTH were lower in PD patients [p<0.05 in both]. Patients on CAPD exhibited significant correction of anaemia during the first six months of treatment and had a better erythropoietin response than the hemodialysis patients