[Comparison the effects of dietary administration of isomeric fatty acids on chemical kindling in second generation of wistar kindled rats]

ABSTRACT

Impressive researches demonstrate the importance of essential fatty acids for many physiological and behavioral mechanisms in both humans and animals. Essential fatty acids must be supplied via the diet. In this study we assessed the dietary effects of cis and trans fatty acids on seizures induced by Pentylenetetrazol [PTZ] in rats. In this experimental study animals were divided into four groups. In the three case groups; cis, trans or cis + trans fatty acids were added to the standard food of rats and in control group only standard food was dietary administrated. After one month, kindling was established in rats with PTZ in subconvulsive dose [45mg/kg i.p.]. Convulsing activities were monitored for 20 mm. Five stages of convulsing activities were observed. If after three consecutive sessions the animal was in the fifth stage, it was considered as a kindled animal. Data was analyzed using K-S, T, Tukey tests and analysis of variance. Results showed that the convulsion stage in trans group was significantly more than others. Also it was found that duration of the fifth stage in trans group was significantly more than control and cis groups. Results suggest that, administering sis and trans fatty acids have some effects on PTZ induced kindling in second generation of the rats who were kindled before. More severe seizure and longer duration of seizure was seen in trans group comparing to cis group