Effects of nandrolone decanoate in bones of female albino rats: a mineral mapped study

ABSTRACT

To map out comparable differential of BMD in lumbosacral vertebrae and proximal half of femur of ageing female Albino rats in relation to Nandrolone decanoate treatment. Study was conducted at Basic Medical Sciences Institute [BMSI] Jinnah Postgraduate Medical Centre [JPMC], Karachi and Osteoporotic Diagnostic Clinic [ODC] Modern Diagnostic Services, BMCHS, Karachi. Ten specimens each of lumbosacral vertebrae [axial bone] and of Proximal half of femur [appendicular bone] of female albino rats were used for observations. Five rats were in experimental group., treated with nandrolone and rest five were taken as controls. Quantitative measurement of BMD [Bone Mineral Density] in bones mapped out with DEXA [Dual Energy X-ray Absorptiometry] scan. Vertebral and femoral BMD showed slight increase in case of experimental group as compared to Control. The results indicate that NandroIone Decanoate exerts positive effects on axial arid appendicular BMD in this preliminary study, thus increased bone mass against involutional Osteoporosis in ageing female Albino rats